Positive regulation of glycogen metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of glycogen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFX1, EPB41L1, and ZKSCAN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glycogen metabolic process activity versus NFX1 in LUNG_SCLC (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NFX1 →	-0.536	-0.707	<.001	.006	3	4
OESOPHAGUS	EPB41L1 →	+1.719	+0.964	.006	.008	3	3
SOFT_TISSUE	ZKSCAN1 →	-0.643	-1.540	.004	<.001	3	3
SOFT_TISSUE	PDCL3 →	+0.949	+1.517	.004	<.001	3	3
LIVER	UNC93A →	-2.996	-1.593	<.001	.001	3	3
LIVER	PROX1 →	-4.773	-1.604	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070875 vs NFX1 — LUNG_SCLC

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