Negative regulation of glycogen metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of glycogen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBA3, GOLGB1, and SLC4A11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glycogen metabolic process activity versus UBA3 in BLOOD_Leukemia (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UBA3 →	+0.347	+0.631	.007	.008	3	5
BLOOD_Myeloma	GOLGB1 →	+0.967	+0.350	.004	.004	3	5
KIDNEY	SLC4A11 →	+2.587	+0.307	<.001	.001	3	4
OESOPHAGUS	PPP1CB →	+0.888	+0.397	.003	.006	3	4
BLOOD_Leukemia	MSL2 →	+1.145	+0.689	<.001	.004	3	4
PANCREAS	USF3 →	+0.634	+0.450	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070874 vs UBA3 — BLOOD_Leukemia

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