Regulation of glycogen metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of glycogen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF280C, SH3KBP1, and RBM3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF280C grouped by Regulation of glycogen metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZNF280C →	-0.641	-0.874	.002	.004	3	4
BREAST	SH3KBP1 →	-1.338	-0.716	.006	.003	3	4
SKIN	RBM3 →	-0.436	-0.620	.005	.007	3	3
LUNG_NSCLC_LUSC	USP27X →	-0.812	-1.126	.001	.003	3	3
BREAST	SLC25A5 →	-0.625	-0.810	.008	.005	3	3
PANCREAS	MELK →	-0.920	-0.823	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF280C by Regulation of glycogen metabolic process activity — BREAST

Explore this box plot interactively →