Regulation of glycogen metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of glycogen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF250, IRS2, and NMT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glycogen metabolic process activity versus ZNF250 in BLOOD_Leukemia (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF250 →	+0.523	+0.478	.001	.004	3	5
LUNG_NSCLC_LUAD	IRS2 →	-1.131	-0.922	.002	<.001	3	5
LIVER	NMT2 →	+1.952	+1.642	.003	<.001	3	4
URINARY_TRACT	TMEM184A →	-2.801	-1.200	.003	.005	3	4
BONE	CCDC77 →	+1.338	+1.252	.002	.002	3	4
BONE	ZNF384 →	+0.844	+1.266	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070873 vs ZNF250 — BLOOD_Leukemia

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