Positive regulation of protein exit from endoplasmic reticulum

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein exit from endoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the KICH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL8B, EDEM1, and SAR1B, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein exit from endoplasmic reticulum activity versus ARL8B in KICH (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	ARL8B →	+0.835	+0.064	<.001	<.001	3	28
CHOL	EDEM1 →	+1.051	+0.078	.008	.008	1	30
CHOL	SAR1B →	+1.058	+0.089	.001	.003	2	28
UVM	MAP3K2 →	+1.146	+0.035	<.001	<.001	3	27
DLBC	ACAP2 →	+1.021	+0.051	<.001	<.001	3	26
DLBC	SORL1 →	+2.282	+0.049	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070863 vs ARL8B — KICH

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