Positive regulation of protein exit from endoplasmic reticulum

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein exit from endoplasmic reticulum pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARFGEF3_S1991, SYT17_S110, and MAOA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein exit from endoplasmic reticulum activity versus ARFGEF3_S1991 in CCRCC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ARFGEF3_S1991 →	+0.791	+0.053	<.001	<.001	3	8
LUAD	SYT17_S110 →	+0.715	+0.061	<.001	<.001	3	6
BRCA	MAOA →	+0.743	+0.060	.001	<.001	3	6
BRCA	ARFGEF3 →	+0.448	+0.053	<.001	<.001	3	6
BRCA	SORL1 →	+0.628	+0.081	<.001	<.001	3	6
BRCA	CD63 →	+0.693	+0.067	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070863 vs ARFGEF3_S1991 — CCRCC

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