Positive regulation of protein exit from endoplasmic reticulum

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein exit from endoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF23, SPEG, and SEC31A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF23 grouped by Positive regulation of protein exit from endoplasmic reticulum-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZNF23 →	-0.600	-0.222	.004	.005	3	6
LUNG_NSCLC_LUSC	SPEG →	-1.795	-0.241	.001	<.001	3	4
LUNG_NSCLC_LUSC	SEC31A →	-1.303	-0.354	.001	<.001	3	4
LUNG_NSCLC_LUSC	EHD2 →	-2.765	-0.217	.001	.003	2	5
LUNG_NSCLC_LUAD	LRRC17 →	+0.389	+0.155	.002	.002	3	3
LUNG_NSCLC_LUAD	B3GNT7 →	+1.324	+0.218	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF23 by Positive regulation of protein exit from endoplasmic reticulum activity — STOMACH

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