Positive regulation of protein exit from endoplasmic reticulum

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein exit from endoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB10, SEC24C, and CMTM8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein exit from endoplasmic reticulum activity versus ZBTB10 in BREAST (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZBTB10 →	-1.861	-0.379	<.001	.002	3	5
LUNG_NSCLC_LUSC	SEC24C →	+1.409	+0.493	.001	.002	3	5
URINARY_TRACT	CMTM8 →	-2.142	-0.217	<.001	.009	3	4
SKIN	MOSMO →	+0.821	+0.195	.009	.001	3	4
LUNG_NSCLC_LUAD	AGAP5 →	+0.654	+0.231	.002	.009	3	4
LUNG_NSCLC_LUSC	ECD →	+0.990	+0.415	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070863 vs ZBTB10 — BREAST

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