Negative regulation of protein exit from endoplasmic reticulum

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein exit from endoplasmic reticulum pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARID4B, SMAD4, and YWHAE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein exit from endoplasmic reticulum activity versus ARID4B in LSCC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARID4B →	+0.222	+0.039	.001	.007	3	5
HNSC	SMAD4 →	+0.228	+0.094	<.001	<.001	3	5
OV	YWHAE →	+0.275	+0.050	.003	<.001	3	5
LSCC	ANP32E →	+0.333	+0.039	<.001	<.001	3	5
PDAC	OFD1_S899 →	+0.356	+0.048	.004	.003	3	5
BRCA	RO60 →	+0.156	+0.031	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070862 vs ARID4B — LSCC

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