Negative regulation of protein exit from endoplasmic reticulum

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein exit from endoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SBK1, PROB1, and EPHA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SBK1 grouped by Negative regulation of protein exit from endoplasmic reticulum-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SBK1 →	+1.665	+1.312	.004	.002	2	6
BLOOD_Leukemia	PROB1 →	+1.118	+1.065	.007	.004	3	4
STOMACH	EPHA1 →	+2.157	+0.872	.008	.006	3	4
SKIN	HTRA2 →	-0.750	-1.032	.003	.006	3	4
LUNG_SCLC	TNFAIP8 →	+0.918	+0.745	.004	.007	3	4
BLOOD_Leukemia	CAPRIN1 →	+0.466	+0.964	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SBK1 by Negative regulation of protein exit from endoplasmic reticulum activity — SOFT_TISSUE

Explore this box plot interactively →