Regulation of protein exit from endoplasmic reticulum

Across TCGA patient cohorts, RNA activity of the Regulation of protein exit from endoplasmic reticulum pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIGIRR, MLPH_S337, and GCC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein exit from endoplasmic reticulum activity versus SIGIRR in BRCA (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SIGIRR →	+0.638	+0.056	<.001	<.001	3	5
BRCA	MLPH_S337 →	+1.279	+0.063	<.001	<.001	3	5
BRCA	GCC2 →	+0.305	+0.044	<.001	<.001	3	5
BRCA	ARFGEF3 →	+0.644	+0.056	<.001	<.001	3	5
BRCA	MAPK9 →	+0.351	+0.056	<.001	<.001	3	5
CCRCC	ATP1A1 →	+0.220	+0.032	.005	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070861 vs SIGIRR — BRCA

Explore this scatter interactively →