Response to epidermal growth factor

Across TCGA patient cohorts, RNA activity of the Response to epidermal growth factor pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNQ1, ARHGAP44, and MSN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to epidermal growth factor activity versus KCNQ1 in PDAC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	KCNQ1 →	-0.545	-0.125	.001	.001	3	4
COAD	ARHGAP44 →	-0.550	-0.274	.005	.002	3	4
LUAD	MSN →	+0.315	+0.117	.008	.005	2	5
PDAC	BICDL1 →	-0.410	-0.128	.009	.002	3	4
PDAC	SCGB3A2 →	+0.697	+0.144	<.001	.007	3	4
CCRCC	SFTA1P →	+0.584	+0.143	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070849 vs KCNQ1 — PDAC

Explore this scatter interactively →