Response to epidermal growth factor

Across TCGA cell cohorts, RNA activity of the Response to epidermal growth factor pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TICAM2, SEL1L3, and SLC26A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TICAM2 grouped by Response to epidermal growth factor-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TICAM2 →	-1.204	-0.335	.001	.002	3	4
LUNG_NSCLC_LUSC	SEL1L3 →	+2.448	+0.382	.009	.002	3	4
LUNG_NSCLC_LUAD	SLC26A2 →	-1.167	-0.166	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ANO9 →	+1.686	+0.139	.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	TUSC1 →	-1.445	-0.223	.002	.005	3	4
LUNG_NSCLC_LUAD	FAM114A2 →	-0.778	-0.172	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TICAM2 by Response to epidermal growth factor activity — KIDNEY

Explore this box plot interactively →