Response to epidermal growth factor

Across TCGA cell cohorts, RNA activity of the Response to epidermal growth factor pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ROGDI, ATPSCKMT, and RAG2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ROGDI grouped by Response to epidermal growth factor-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ROGDI →	-0.242	-0.116	<.001	<.001	3	6
LARGE_INTESTINE	ATPSCKMT →	-0.343	-0.078	.003	.008	2	6
LUNG_SCLC	RAG2 →	+0.278	+0.114	<.001	<.001	3	4
LUNG_SCLC	GP1BA →	+0.149	+0.105	.002	<.001	3	4
LUNG_SCLC	CFLAR →	+0.303	+0.092	.002	.004	3	4
LUNG_NSCLC_LUSC	ANXA13 →	-0.166	-0.088	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ROGDI by Response to epidermal growth factor activity — LUNG_SCLC

Explore this box plot interactively →