Response to epidermal growth factor

Across TCGA cell cohorts, RNA activity of the Response to epidermal growth factor pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NABP2, HMCES, and RBM38, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to epidermal growth factor activity versus NABP2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NABP2 →	+0.955	+0.232	<.001	.004	3	5
SOFT_TISSUE	HMCES →	+1.069	+0.228	<.001	.001	3	5
PANCREAS	RBM38 →	+1.258	+0.228	.002	.009	3	4
SKIN	IDH3A →	+0.927	+0.231	<.001	<.001	3	4
SKIN	COPRS →	+1.087	+0.328	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	RPE →	+1.068	+0.224	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070849 vs NABP2 — UPPER_AERODIGESTIVE_TRACT

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