Aggresome assembly

Across TCGA patient cohorts, RNA activity of the Aggresome assembly pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HDAC6, TRIM37, and ZMYM3, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aggresome assembly activity versus HDAC6 in UCS (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	HDAC6 →	+0.945	+0.087	.005	.003	2	27
DLBC	TRIM37 →	+1.000	+0.060	<.001	<.001	3	26
DLBC	ZMYM3 →	+0.851	+0.051	<.001	<.001	3	25
DLBC	PRPF4B →	+0.934	+0.058	<.001	<.001	3	25
DLBC	RSKR →	+0.935	+0.059	<.001	<.001	3	25
DLBC	HUWE1 →	+1.183	+0.059	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070842 vs HDAC6 — UCS

Explore this scatter interactively →