Aggresome assembly

Across TCGA patient cohorts, RNA activity of the Aggresome assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAGED2, ZNF608_S1453, and PDK3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aggresome assembly activity versus MAGED2 in BRCA (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAGED2 →	+0.398	+0.047	<.001	<.001	3	5
PDAC	ZNF608_S1453 →	+0.516	+0.046	.001	.001	3	5
COAD	PDK3 →	+0.439	+0.064	<.001	<.001	3	5
OV	ITGB5 →	+0.484	+0.060	<.001	.001	3	5
CCRCC	CTHRC1 →	+0.691	+0.028	.001	.007	3	4
CCRCC	ITGB1 →	+0.164	+0.036	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070842 vs MAGED2 — BRCA

Explore this scatter interactively →