Aggresome assembly

Across TCGA patient cohorts, RNA activity of the Aggresome assembly pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGAM1, DENND10, and FAM241B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aggresome assembly activity versus PGAM1 in CCRCC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PGAM1 →	+0.488	+0.449	<.001	<.001	3	4
GBM	DENND10 →	+0.332	+0.156	<.001	.004	3	3
UCEC	FAM241B →	+0.551	+0.641	.008	.002	3	3
CCRCC	EGR1 →	-1.060	-0.287	.001	.003	3	3
LSCC	LINC02381 →	-0.577	-0.792	<.001	<.001	3	3
LSCC	NDUFA4L2 →	+1.080	+0.587	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070842 vs PGAM1 — CCRCC

Explore this scatter interactively →