Inclusion body assembly

Across TCGA patient cohorts, RNA activity of the Inclusion body assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IVNS1ABP, HSPB8, and CCDC74A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inclusion body assembly activity versus IVNS1ABP in BRCA (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IVNS1ABP →	-0.356	-0.180	.007	.002	3	4
UCEC	HSPB8 →	+1.104	+0.165	.003	.008	3	4
BRCA	CCDC74A →	+1.512	+0.224	.001	.001	3	4
BRCA	RAB26 →	+0.765	+0.192	.003	<.001	3	4
LSCC	HOMER2 →	+0.572	+0.185	.006	<.001	3	4
UCEC	CFAP61 →	+0.814	+0.153	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070841 vs IVNS1ABP — BRCA

Explore this scatter interactively →