Inclusion body assembly

Across TCGA patient cohorts, RNA activity of the Inclusion body assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BAG3_S275, BAG3_S195, and BAG3_S289, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inclusion body assembly activity versus BAG3_S275 in BRCA (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BAG3_S275 →	+1.241	+0.302	<.001	<.001	3	4
HNSC	BAG3_S195 →	+0.485	+0.179	<.001	<.001	3	3
OV	BAG3_S289 →	+0.622	+0.257	<.001	<.001	3	3
BRCA	GLCCI1_S30 →	+0.316	+0.333	.001	.001	3	3
OV	BAG3_S173 →	+1.072	+0.176	<.001	.003	3	3
UCEC	CC2D1A_S253 →	+0.361	+0.138	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070841 vs BAG3_S275 — BRCA

Explore this scatter interactively →