Inclusion body assembly

Across TCGA cell cohorts, RNA activity of the Inclusion body assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PFDN2, HMGB3, and SP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PFDN2 grouped by Inclusion body assembly-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PFDN2 →	+0.510	+0.636	.001	.008	3	5
LIVER	HMGB3 →	+0.916	+1.580	<.001	<.001	3	4
OVARY	SP4 →	+0.519	+1.018	<.001	<.001	3	4
OVARY	SET →	+0.616	+0.961	.005	.003	3	4
OVARY	SEMA3B →	-2.428	-1.177	.005	<.001	3	4
KIDNEY	STK26 →	+2.161	+1.348	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PFDN2 by Inclusion body assembly activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →