Inclusion body assembly

Across TCGA cell cohorts, RNA activity of the Inclusion body assembly pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAFK, TNFRSF11A, and CGN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inclusion body assembly activity versus MAFK in CNS (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MAFK →	+1.633	+0.218	.009	.001	3	4
BREAST	TNFRSF11A →	+1.104	+0.220	<.001	<.001	3	4
LARGE_INTESTINE	CGN →	-2.024	-0.102	.001	<.001	3	4
LARGE_INTESTINE	DBI →	+0.925	+0.093	.001	.001	3	4
LUNG_SCLC	ZNF200 →	-0.414	-0.202	.008	.006	3	4
CNS	HMOX1 →	+2.729	+0.218	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070841 vs MAFK — CNS

Explore this scatter interactively →