Dehydroascorbic acid transport

Across TCGA patient cohorts, RNA activity of the Dehydroascorbic acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FCER1G, NCF2, and TRPM2_S38, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dehydroascorbic acid transport activity versus FCER1G in GBM (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FCER1G →	+0.593	+0.091	<.001	<.001	3	7
GBM	NCF2 →	+0.591	+0.109	<.001	<.001	3	7
CCRCC	TRPM2_S38 →	+0.577	+0.064	.001	<.001	3	6
LSCC	DNAJC13 →	+0.213	+0.078	<.001	.001	3	6
GBM	HK3 →	+0.717	+0.105	<.001	<.001	3	6
LSCC	MNDA →	+0.698	+0.084	<.001	<.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070837 vs FCER1G — GBM

Explore this scatter interactively →