Caveola assembly

Across TCGA patient cohorts, RNA activity of the Caveola assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIP6, AHNAK, and PPL, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Caveola assembly activity versus TRIP6 in LUAD (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TRIP6 →	+0.357	+0.171	<.001	<.001	3	9
UCEC	AHNAK →	+0.497	+0.136	<.001	<.001	3	8
OV	PPL →	+0.950	+0.095	<.001	<.001	3	8
COAD	ARHGEF17 →	+0.379	+0.051	<.001	.001	3	8
UCEC	SMARCA5 →	-0.219	-0.143	<.001	<.001	3	7
BRCA	SRPK1_S311 →	-0.770	-0.076	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070836 vs TRIP6 — LUAD

Explore this scatter interactively →