Caveola assembly

Across TCGA cell cohorts, RNA activity of the Caveola assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEAD1, RBX1, and MBD5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEAD1 grouped by Caveola assembly-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TEAD1 →	+0.775	+0.323	<.001	<.001	3	8
BONE	RBX1 →	-0.351	-0.157	.004	.001	3	5
LIVER	MBD5 →	+0.308	+0.234	<.001	.002	3	5
LIVER	PKN2 →	+0.532	+0.296	.003	.002	3	5
SOFT_TISSUE	MAX →	-0.485	-0.170	<.001	.009	3	5
STOMACH	ZNF101 →	-0.194	-0.283	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEAD1 by Caveola assembly activity — LIVER

Explore this box plot interactively →