Caveola assembly

Across TCGA cell cohorts, RNA activity of the Caveola assembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PACSIN2, CATSPER1, and TRIOBP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Caveola assembly activity versus PACSIN2 in BREAST (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PACSIN2 →	+1.004	+0.269	<.001	.001	2	8
OVARY	CATSPER1 →	+1.691	+0.287	.003	.001	3	6
OESOPHAGUS	TRIOBP →	+0.956	+0.146	.001	.006	3	5
OESOPHAGUS	CAPN1 →	+1.466	+0.198	.001	.002	3	5
BLOOD_Leukemia	PDLIM7 →	+0.787	+0.195	.005	.005	3	5
BLOOD_Lymphoma	FLOT1 →	+2.175	+0.354	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070836 vs PACSIN2 — BREAST

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