Basement membrane assembly

Across TCGA patient cohorts, RNA activity of the Basement membrane assembly pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2_S120, VWF, and FMNL3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Basement membrane assembly activity versus TNS2_S120 in UCEC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TNS2_S120 →	+0.498	+0.097	<.001	<.001	3	10
UCEC	VWF →	+0.549	+0.098	<.001	.002	3	10
UCEC	FMNL3 →	+0.390	+0.117	<.001	<.001	3	10
HNSC	LAMC1 →	+0.479	+0.099	<.001	<.001	3	10
HNSC	NID1 →	+0.589	+0.117	<.001	<.001	3	10
OV	PTGES3 →	-0.294	-0.050	.002	.004	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070831 vs TNS2_S120 — UCEC

Explore this scatter interactively →