Heterochromatin organization

Across TCGA patient cohorts, RNA activity of the Heterochromatin organization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PBRM1, DHX32, and ZMYM4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heterochromatin organization activity versus PBRM1 in GBM (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PBRM1 →	+0.368	+0.053	<.001	<.001	3	7
COAD	DHX32 →	-0.313	-0.033	.003	.003	3	7
HNSC	ZMYM4 →	+0.307	+0.092	<.001	<.001	3	6
GBM	CHD4 →	+0.213	+0.031	.002	<.001	3	6
GBM	GMPPA →	-0.286	-0.044	<.001	<.001	3	6
GBM	MTA1 →	+0.499	+0.046	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070828 vs PBRM1 — GBM

Explore this scatter interactively →