Hydrogen sulfide metabolic process

Across TCGA patient cohorts, RNA activity of the Hydrogen sulfide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTH, BAK1, and GRK2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hydrogen sulfide metabolic process activity versus CTH in COAD (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CTH →	+0.595	+0.165	<.001	<.001	3	6
UCEC	BAK1 →	-0.502	-0.106	.005	.001	3	5
PDAC	GRK2 →	-0.371	-0.140	<.001	<.001	3	4
UCEC	DDX23 →	-0.844	-0.155	.005	.001	3	4
COAD	TMEM30BP1 →	-0.454	-0.151	<.001	<.001	3	4
HNSC	PYCARD →	-0.917	-0.162	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070813 vs CTH — COAD

Explore this scatter interactively →