Hydrogen sulfide metabolic process

Across TCGA cell cohorts, RNA activity of the Hydrogen sulfide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf162, TNFRSF25, and CMTM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C1orf162 grouped by Hydrogen sulfide metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C1orf162 →	+0.300	+0.827	<.001	.006	3	3
OVARY	TNFRSF25 →	+1.342	+1.095	.009	.004	3	3
PANCREAS	CMTM1 →	+1.068	+1.762	.001	<.001	3	3
PANCREAS	SCN9A →	+1.181	+1.404	.008	<.001	3	3
SOFT_TISSUE	HPS4 →	+0.913	+1.531	.003	.004	3	3
SOFT_TISSUE	PAIP2 →	+0.516	+1.382	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C1orf162 by Hydrogen sulfide metabolic process activity — OVARY

Explore this box plot interactively →