Hydrogen sulfide metabolic process

Across TCGA cell cohorts, RNA activity of the Hydrogen sulfide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM147, STX1A, and PCDH12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hydrogen sulfide metabolic process activity versus TMEM147 in BLOOD_Leukemia (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM147 →	+0.819	+0.227	<.001	.002	3	4
BLOOD_Lymphoma	STX1A →	+2.160	+1.071	<.001	.008	3	3
BLOOD_Lymphoma	PCDH12 →	+0.546	+1.093	<.001	.007	3	3
BLOOD_Lymphoma	SOGA1 →	-2.154	-0.782	<.001	.008	3	3
BLOOD_Lymphoma	ZFYVE28 →	+3.736	+1.096	<.001	.007	3	3
OESOPHAGUS	CXCL1 →	+3.821	+0.317	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070813 vs TMEM147 — BLOOD_Leukemia

Explore this scatter interactively →