Phosphatidylserine exposure on apoptotic cell surface

Across TCGA patient cohorts, RNA activity of the Phosphatidylserine exposure on apoptotic cell surface pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SVIL, TAP1, and TAP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylserine exposure on apoptotic cell surface activity versus SVIL in CCRCC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SVIL →	-0.477	-0.070	<.001	<.001	3	7
BRCA	TAP1 →	+0.656	+0.076	<.001	<.001	3	7
BRCA	TAP2 →	+0.703	+0.066	.002	<.001	3	7
LSCC	PSME2 →	+0.341	+0.054	<.001	<.001	3	7
HNSC	PTPRC →	+0.510	+0.073	<.001	<.001	3	7
BRCA	SP110_S380 →	+0.721	+0.066	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070782 vs SVIL — CCRCC

Explore this scatter interactively →