Phosphatidylserine exposure on apoptotic cell surface

Across TCGA cell cohorts, RNA activity of the Phosphatidylserine exposure on apoptotic cell surface pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDPN, DOCK4, and MED13L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDPN grouped by Phosphatidylserine exposure on apoptotic cell surface-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PDPN →	+0.430	+0.448	<.001	<.001	3	4
BREAST	DOCK4 →	-0.145	-0.780	.004	.004	3	4
SOFT_TISSUE	MED13L →	+0.128	+1.355	.007	.005	3	3
SOFT_TISSUE	PRDM7 →	+0.228	+0.353	.003	.001	3	3
SOFT_TISSUE	PDE5A →	-0.252	-0.809	<.001	.009	3	3
SOFT_TISSUE	FAM186A →	-0.294	-0.965	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDPN by Phosphatidylserine exposure on apoptotic cell surface activity — STOMACH

Explore this box plot interactively →