D-aspartate import across plasma membrane

Across TCGA patient cohorts, RNA activity of the D-aspartate import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UTP25, TPR, and ADNP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, D-aspartate import across plasma membrane activity versus UTP25 in BRCA (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	UTP25 →	-0.349	-0.088	.001	.004	3	6
LSCC	TPR →	-0.211	-0.127	<.001	<.001	3	5
COAD	ADNP →	-0.203	-0.094	.001	<.001	3	5
COAD	MSR1 →	+0.399	+0.108	.008	<.001	3	5
UCEC	BST2 →	+0.978	+0.103	<.001	.004	3	5
LSCC	POLR1B →	-0.225	-0.070	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070779 vs UTP25 — BRCA

Explore this scatter interactively →