D-aspartate import across plasma membrane

Across TCGA patient cohorts, RNA activity of the D-aspartate import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC1A3, MIR600HG, and SNORD115-9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, D-aspartate import across plasma membrane activity versus SLC1A3 in GBM (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC1A3 →	+0.775	+0.260	<.001	<.001	3	4
COAD	MIR600HG →	-0.782	-0.307	<.001	.003	3	4
GBM	SNORD115-9 →	+0.646	+0.214	.003	.003	3	3
GBM	SNORD115-32 →	+1.112	+0.260	<.001	<.001	3	3
UCEC	CCSER1 →	+1.396	+0.653	<.001	.009	3	3
UCEC	SDAD1P1 →	+1.146	+0.535	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070779 vs SLC1A3 — GBM

Explore this scatter interactively →