D-aspartate import across plasma membrane

Across TCGA cell cohorts, RNA activity of the D-aspartate import across plasma membrane pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GFAP, SELPLG, and SLC1A1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GFAP grouped by D-aspartate import across plasma membrane-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GFAP →	-0.415	-2.004	.002	<.001	3	12
BLOOD_Myeloma	SELPLG →	-0.487	-1.864	.003	<.001	3	6
LUNG_NSCLC_LUSC	SLC1A1 →	-0.288	-1.238	.007	.002	2	7
SOFT_TISSUE	NTSR1 →	-0.292	-1.437	.005	<.001	3	6
BLOOD_Leukemia	SLC1A3 →	-0.249	-1.100	<.001	<.001	3	5
CNS	BCL2L14 →	-0.163	-1.161	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GFAP by D-aspartate import across plasma membrane activity — LUNG_SCLC

Explore this box plot interactively →