L-aspartate transmembrane transport

Across TCGA patient cohorts, RNA activity of the L-aspartate transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM21, ICAM1, and AIF1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-aspartate transmembrane transport activity versus TRIM21 in HNSC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRIM21 →	+0.385	+0.054	<.001	.001	3	6
LSCC	ICAM1 →	+0.474	+0.062	<.001	<.001	3	6
LSCC	AIF1 →	+0.338	+0.060	<.001	<.001	3	6
CCRCC	THEMIS2 →	+0.308	+0.065	<.001	<.001	3	6
CCRCC	TRPM2_S38 →	+0.742	+0.088	<.001	<.001	3	6
GBM	WAS →	+0.439	+0.059	.007	.005	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070778 vs TRIM21 — HNSC

Explore this scatter interactively →