L-aspartate transmembrane transport

Across TCGA patient cohorts, RNA activity of the L-aspartate transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VIM, LIN7B, and ZBTB16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-aspartate transmembrane transport activity versus VIM in PDAC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	VIM →	-0.632	-0.313	<.001	.004	3	5
BRCA	LIN7B →	+0.456	+0.290	<.001	<.001	3	5
HNSC	ZBTB16 →	-0.817	-0.181	.007	.001	3	4
HNSC	MGP →	-1.053	-0.142	<.001	<.001	3	4
OV	SFRP2 →	-2.036	-0.184	.007	.001	3	4
HNSC	DAAM2 →	-0.607	-0.222	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070778 vs VIM — PDAC

Explore this scatter interactively →