L-aspartate transmembrane transport

Across TCGA cell cohorts, RNA activity of the L-aspartate transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAZ, SGK1, and PRMT9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAZ grouped by L-aspartate transmembrane transport-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TAZ →	-0.948	-1.226	.004	.001	3	4
LUNG_NSCLC_LUAD	SGK1 →	-1.196	-0.806	.008	<.001	3	4
LUNG_SCLC	PRMT9 →	-0.753	-0.947	<.001	.006	3	4
STOMACH	IL6R →	-1.827	-1.135	.007	.001	3	4
SKIN	ANXA5 →	-0.719	-1.073	.003	.002	3	4
BLOOD_Myeloma	NDRG4 →	+2.242	+1.789	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAZ by L-aspartate transmembrane transport activity — OESOPHAGUS

Explore this box plot interactively →