L-aspartate transmembrane transport

Across TCGA cell cohorts, RNA activity of the L-aspartate transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLTP, MYG1, and CXXC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-aspartate transmembrane transport activity versus GLTP in LARGE_INTESTINE (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GLTP →	-0.678	-0.245	.009	.005	3	4
LARGE_INTESTINE	MYG1 →	-0.387	-0.181	.001	.002	3	4
URINARY_TRACT	CXXC1 →	-1.089	-0.340	.003	.001	3	4
BREAST	SLC1A5 →	+0.830	+0.270	.002	.002	3	4
OVARY	SLC25A13 →	+0.891	+0.287	.001	.009	3	4
OESOPHAGUS	OCIAD1 →	-0.576	-0.237	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070778 vs GLTP — LARGE_INTESTINE

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