Response to interleukin-6

Across TCGA patient cohorts, RNA activity of the Response to interleukin-6 pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB1, CD53, and TLR8, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-6 activity versus LILRB1 in SCLC (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	LILRB1 →	+1.786	+0.181	<.001	<.001	3	33
KICH	CD53 →	+1.951	+0.049	<.001	<.001	3	33
LAML	TLR8 →	+2.213	+0.056	<.001	<.001	3	32
SCLC	CXorf21 →	+1.081	+0.124	<.001	<.001	3	32
DLBC	FGL2 →	+1.782	+0.064	<.001	<.001	3	32
SKCM	GPR65 →	+0.998	+0.041	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070741 vs LILRB1 — SCLC

Explore this scatter interactively →