Response to interleukin-6

Across TCGA patient cohorts, RNA activity of the Response to interleukin-6 pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPP1, ADAMTSL4, and GDF9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-6 activity versus TPP1 in GBM (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TPP1 →	+0.513	+0.200	<.001	<.001	3	5
GBM	ADAMTSL4 →	+0.429	+0.201	.006	<.001	3	5
UCEC	GDF9 →	-0.357	-0.162	.001	<.001	3	4
UCEC	MIR223HG →	+0.910	+0.142	.001	.008	3	4
GBM	RIN3 →	+0.552	+0.206	<.001	<.001	3	4
GBM	MYO1F →	+0.740	+0.240	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070741 vs TPP1 — GBM

Explore this scatter interactively →