Response to interleukin-6

Across TCGA cell cohorts, RNA activity of the Response to interleukin-6 pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D20, ALKBH1, and COPS8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBC1D20 grouped by Response to interleukin-6-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D20 →	-0.651	-0.229	.007	.005	3	4
BLOOD_Leukemia	ALKBH1 →	+0.419	+0.295	.002	<.001	3	3
BLOOD_Leukemia	COPS8 →	+0.882	+0.295	.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	AURKAIP1 →	+0.738	+0.266	.002	.002	3	3
UPPER_AERODIGESTIVE_TRACT	NOC2L →	+0.818	+0.267	.003	.001	3	3
SKIN	SPDYE6 →	-0.670	-0.760	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBC1D20 by Response to interleukin-6 activity — LARGE_INTESTINE

Explore this box plot interactively →