Cyclic nucleotide transport

Across TCGA cell cohorts, RNA activity of the Cyclic nucleotide transport pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPM1, RILPL2, and PRR16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TPM1 grouped by Cyclic nucleotide transport-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TPM1 →	-1.808	-0.787	<.001	.001	3	4
KIDNEY	RILPL2 →	-0.744	-1.363	.001	.002	3	4
SKIN	PRR16 →	-0.790	-0.791	.009	.001	3	4
LUNG_NSCLC_LUAD	KCNN4 →	-1.531	-0.891	.004	<.001	3	4
SKIN	PRKAG2 →	-1.066	-0.819	.001	<.001	3	3
SKIN	WNT5B →	-2.020	-1.191	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TPM1 by Cyclic nucleotide transport activity — SKIN

Explore this box plot interactively →