Response to interleukin-18

Across TCGA patient cohorts, RNA activity of the Response to interleukin-18 pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAMC2, ANXA2, and ARPC1B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-18 activity versus LAMC2 in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LAMC2 →	+0.722	+0.067	<.001	<.001	3	8
BRCA	ANXA2 →	+0.431	+0.040	<.001	<.001	3	7
GBM	ARPC1B →	+0.441	+0.093	<.001	<.001	3	7
LSCC	LAMB3 →	+0.701	+0.068	<.001	<.001	3	7
BRCA	PLEC →	+0.373	+0.067	<.001	<.001	3	7
BRCA	S100A10 →	+0.488	+0.043	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070673 vs LAMC2 — LSCC

Explore this scatter interactively →