Response to interleukin-18

Across TCGA patient cohorts, RNA activity of the Response to interleukin-18 pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL23, TNFSF13B, and RIPK2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-18 activity versus KLHL23 in CCRCC (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KLHL23 →	-0.604	-0.783	<.001	<.001	3	6
LSCC	TNFSF13B →	+0.882	+0.593	<.001	<.001	3	4
CCRCC	RIPK2 →	+0.450	+0.697	<.001	<.001	3	4
LSCC	CD86 →	+0.543	+0.431	<.001	<.001	3	4
CCRCC	KLHDC7B →	+0.399	+0.606	.001	.005	3	4
CCRCC	PTGR2 →	-0.439	-0.621	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070673 vs KLHL23 — CCRCC

Explore this scatter interactively →