Response to interleukin-18

Across TCGA cell cohorts, RNA activity of the Response to interleukin-18 pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEXIM2, C18orf54, and CCNE2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-18 activity versus HEXIM2 in LUNG_NSCLC_LUAD (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HEXIM2 →	+1.432	+1.369	.003	.009	3	4
LUNG_NSCLC_LUAD	C18orf54 →	+0.945	+1.052	.002	.008	3	3
BLOOD_Leukemia	CCNE2 →	+2.214	+1.604	<.001	.006	3	2
OESOPHAGUS	APPL1 →	+0.903	+1.754	.001	<.001	3	2
LUNG_NSCLC_LUAD	MAST1 →	+1.099	+1.057	.006	.008	3	2
LUNG_NSCLC_LUAD	SPATA32 →	+0.769	+1.390	.004	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070673 vs HEXIM2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →