Response to interleukin-12

Across TCGA patient cohorts, RNA activity of the Response to interleukin-12 pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GMIP, TBXAS1, and CTNNA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-12 activity versus GMIP in LSCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GMIP →	+0.337	+0.075	<.001	<.001	3	6
LSCC	TBXAS1 →	+0.412	+0.066	<.001	<.001	3	6
LSCC	CTNNA1 →	-0.325	-0.058	<.001	.004	3	6
HNSC	PSMB9 →	+0.394	+0.079	<.001	<.001	3	6
LSCC	BTK →	+0.616	+0.088	<.001	<.001	3	6
CCRCC	RIPK2 →	+0.283	+0.045	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070671 vs GMIP — LSCC

Explore this scatter interactively →