Response to interleukin-12

Across TCGA patient cohorts, RNA activity of the Response to interleukin-12 pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIPK2, TMEM144, and SH2D2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-12 activity versus RIPK2 in BRCA (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RIPK2 →	+0.607	+0.568	.003	.003	3	4
GBM	TMEM144 →	+1.046	+0.675	.002	.001	3	4
CCRCC	SH2D2A →	+0.374	+0.581	.007	<.001	3	4
HNSC	PRKCQ-AS1 →	+0.877	+0.571	<.001	.003	3	3
PDAC	FCF1 →	-0.265	-0.603	.005	.005	3	3
PDAC	SH3GLB2 →	+0.395	+0.753	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070671 vs RIPK2 — BRCA

Explore this scatter interactively →