Response to interleukin-12

Across TCGA cell cohorts, RNA activity of the Response to interleukin-12 pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD47, PLSCR1, and IFI6, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-12 activity versus CD47 in PANCREAS (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CD47 →	+2.278	+0.335	<.001	<.001	3	12
LARGE_INTESTINE	PLSCR1 →	+1.616	+0.265	<.001	<.001	3	6
LIVER	IFI6 →	+2.560	+0.294	.002	.006	3	6
OVARY	PFAS →	-1.474	-0.294	.001	.002	3	6
CNS	RPS9 →	-0.416	-0.193	.008	.003	3	5
LUNG_NSCLC_LUAD	NSUN6 →	-0.686	-0.157	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070671 vs CD47 — PANCREAS

Explore this scatter interactively →